Technology Platform

(1) Medical platform technology
In the past ten years, Jian Gang has established a systematic method that can make correct evaluation, identification and optimization of active ingredients from various components in single or multiple extracts of single or multiple plants. Various ingredients. This proprietary technology platform is called the drug platform technology and includes the following steps:
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Collect all relevant public documents and conduct data mining through computers and human expertise to detect appropriate information;
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Perform a large number of corresponding in vitro, in situ, in vivo cell or animal models to verify or modify the information obtained from step 1;
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Based on the verified/modified information, the knowledge is extended to the target population or in vivo pharmacokinetic studies and pharmacodynamic studies to verify its clinical effects on the safety and effectiveness of the target disease.
(2) Large database of saponins
Saponins are a group of compounds with multiple therapeutic values that exist in a variety of medicinal plants. Jian Gang obtained an existing database with a broad understanding of the use of saponin by individuals or groups. These big data enable Jiangang to explore the future potential uses of saponins in various plants.
(3) Individual technology and interdisciplinary integration strategy (ITCIS)
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Global GACP plant planting quality control
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Scientific and rational extraction and activity research
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Identification of active ingredients or active groups and quality improvement of pharmacodynamics
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International intellectual property protection and regulatory review strategy declaration
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Commercialization of drug targets and commercialization of regulations
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Perform first-class clinical design to produce results acceptable to the world
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Establishment, marketization and standardization of worldwide drug guidelines
(4) Core competence
Integrate professionals in various fields, establish a cross-field common goal, and work hard for the scientific, modern and internationalization of Chinese plant medicines.
皂苷(Saponin),源我們針對皂苷的藥物研發和應用,經過積累10+aponin Drug Development” (SDD)︐除了能解決以上的問題外︐這大資料平臺將來還能提供實力強大的技術資源給整個中醫產業︓第一︐改被動為主動︓憑著我們團隊對皂苷構造的瞭解和作分拆重組技術的不斷提升︐我
們已掌握一個獲取各式各樣皂苷化合物的方法︐並由此獲得了一個龐大的皂苷資料庫。這個皂苷資料庫能讓我們進行「主動式」篩選︐從蛋白質陣列快速和有系統地測試出各皂苷對人體細胞內的影響︐利用大資料和人工智慧分析出相應的分子途徑︐找出對特定適應症有療效的標靶。
第二︐分拆功能達至單一針對性的藥效︓ 我們的平臺技術能通過合成和修改來去除單一皂苷上的不良活性︐而同時保持其理想的生物活性。例如︐我們団隊已成功改良了歐洲七葉皂苷︐在保持其多種活性療效的同時︐亦消滅其溶血的副作用。經過多年的研究積累︐我們團隊已經獲得了大量具有生物活性的新皂苷化合物︐其中包括一些具有巨大潛力治療多樣癌症︐神經退化︐病毒等等的皂苷化合物。同時︐我們已建立了一個龐大的︐對單體或群體皂苷化合物的特性和使用具有廣泛瞭解的「皂苷資料庫」。該資料庫能讓研究人員對任何新的或未知的皂苷分子的各種特性(包括其藥效和藥代動力特性)作出可靠的、有根據的預測和評估︐從而為研究人員提供指導性的研發方向︐並大大縮短驗證實驗所需的時間。
Tech achievements
The technological achievements that Jian Gang now has are
(1) Pharmaceutical Platform Technology conducts data mining and provides guidance and machine learning for early drug development.
(2) The Saponin Large Database (SBD) provides the existing comprehensive knowledge about saponin compounds.
(3) The scientists and experts of Jiangang have the independent ability to investigate every step and professional knowledge of drug development, and they can also integrate and coordinate all steps of drug development (individual technology and interdisciplinary integration strategy, ITCIS). These steps include plant material growth and GACP control, unique extraction or purification, chemical analysis, fractionation, quantitative and standardized activity, confirmation of absorption components, which can produce unique active ingredients or component group combinations, and develop multi-target products.